Therapeutic effects of KCC2 chloride transporter activation on detrusor overactivity in mice with spinal cord injury-Reference-Cited by-同舟云学术

Therapeutic effects of KCC2 chloride transporter activation on detrusor overactivity in mice with spinal cord injury

Published:2023-04-01 Issue:4 Volume:324 Page:F353-F361
ISSN:1931-857X
Container-title:American Journal of Physiology-Renal Physiology
language:en
Short-container-title:American Journal of Physiology-Renal Physiology

Author:

Watanabe Kyohei¹²^ORCID,Ishibashi Masaru¹^ORCID,Suzuki Takahisa³⁴^ORCID,Otsuka Atsushi²^ORCID,Yoshimura Naoki⁵^ORCID,Miyake Hideaki²^ORCID,Fukuda Atsuo¹^ORCID

Affiliation:

1. Department of Neurophysiology, Hamamatsu University School of Medicine, Hamamatsu, Japan

2. Department of Urology, Hamamatsu University School of Medicine, Hamamatsu, Japan

3. Department of Urology, Kanagawa Rehabilitation Hospital, Atsugi, Japan

4. Department of Urology, Yokohama City University, Yokohama, Japan

5. Department of Urology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States

Abstract

This study is the first report to suggest that activation of the Cl− transporter K+-Cl− cotransporter 2 may be a therapeutic modality for the treatment of spinal cord injury-induced detrusor overactivity by targeting bladder efferent pathways.

Funder

Smoking Research Foundation

Salt Science Research Foundation

Japan Epilepsy Research Foundation

MEXT | 理研 | Advanced Science Institute

MEXT | Japan Society for the Promotion of Science

Publisher

American Physiological Society

Subject

Physiology

Link

https://journals.physiology.org/doi/pdf/10.1152/ajprenal.00271.2022

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