Poly(ADP-ribose) polymerase-1 affects vasopressin-mediated AQP2 expression in collecting duct cells of the kidney-Reference-Cited by-同舟云学术

Poly(ADP-ribose) polymerase-1 affects vasopressin-mediated AQP2 expression in collecting duct cells of the kidney

Published:2024-01-01 Issue:1 Volume:326 Page:F69-F85
ISSN:1931-857X
Container-title:American Journal of Physiology-Renal Physiology
language:en
Short-container-title:American Journal of Physiology-Renal Physiology

Author:

Jang Hyo-Ju¹²,Park Euijung¹³,Jung Hyun Jun⁴^ORCID,Kwon Tae-Hwan¹²^ORCID

Affiliation:

1. Department of Biochemistry and Cell Biology, School of Medicine, Kyungpook National University, Taegu, Korea

2. BK21 FOUR KNU Convergence Educational Program, Department of Biomedical Science, School of Medicine, Kyungpook National University, Taegu, Korea

3. Epithelial Systems Biology Center, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, Maryland, United States

4. Division of Nephrology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States

Abstract

The poly(ADP-ribose) polymerase (PARP) family catalyzes poly(ADP-ribosylation) (PARylation), which is one of the posttranslational modifications of largely undetermined physiological significance. This study investigated the role of PARP-1, the most prevalent member of the PARP family, in the vasopressin-responsive expression of aquaporin-2 (AQP2). The results demonstrated that PARP-1 protein expression itself, and not PARP-1-mediated PARylation, is necessary for dDAVP-regulated AQP2 expression. β-Catenin, which is phosphorylated at Ser552 by dDAVP, was identified as the PARP-1-interacting protein.

Funder

Korea Health Industry Development Institute

National Research Foundation of Korea

Publisher

American Physiological Society

Subject

Physiology

Link

https://journals.physiology.org/doi/pdf/10.1152/ajprenal.00144.2023

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1. Corrigendum for Jang et al., volume 326, 2024, p. F69;American Journal of Physiology-Renal Physiology;2024-04-01