Inhaled silica nanoparticles cause chronic kidney disease in rats-Reference-Cited by-同舟云学术

Inhaled silica nanoparticles cause chronic kidney disease in rats

Published:2022-07-01 Issue:1 Volume:323 Page:F48-F58
ISSN:1931-857X
Container-title:American Journal of Physiology-Renal Physiology
language:en
Short-container-title:American Journal of Physiology-Renal Physiology

Author:

Sasai Fumihiko¹,Rogers Keegan L.²,Orlicky David J.³^ORCID,Stem Arthur²,Schaeffer Joshua⁴⁵,Garcia Gabriela¹,Fox Jacob¹^ORCID,Ray Matthew S.¹^ORCID,Butler-Dawson Jaime⁴^ORCID,Gonzalez-Quiroz Marvin⁶^ORCID,Leiva Ricardo⁷,Taduri Gangadhar⁸,Anutrakululchai Sirirat⁹,Venugopal Vidhya¹⁰,Madero Magdalena¹¹,Glaser Jason¹²,Wijkstrom Julia¹³^ORCID,Wernerson Annika¹³,Brown Jared M.²,Johnson Richard J.¹^ORCID,Roncal-Jimenez Carlos A.¹

Affiliation:

1. Division of Renal Disease, University of Colorado Anschutz Medical Campus, Aurora, Colorado

2. Department of Pharmaceutical Sciences, Skaggs School of Pharmacy, University of Colorado Anschutz Medical Campus, Aurora, Colorado

3. Department of Pathology, University of Colorado School of Medicine, Aurora, Colorado

4. Department of Environmental and Radiological Health Sciences, Colorado State University, Fort Collins, Colorado

5. Center for Health, Work & Environment, Department of Environmental and Occupational Health, Colorado School of Public Health, University of Colorado, Aurora, Colorado

6. Centre for Nephrology, University College London, London, United Kingdom

7. Division of Kidney Diseases, Hospital Rosales, San Salvador, El Salvador

8. Division of Nephrology, Nizams Institute of Medical Sciences, Hyderabad, India

9. Division of Kidney Diseases, Khon Kaen University, Khon Kaen, Thailand

10. School of Public Health, Sri Ramachandra Medical College and Research Institute, Chennai, India

11. Division of Kidney Diseases, Instituto Nacional de Cardiología Ignacio Chávez, Mexico City, Mexico

12. La Isla Network, Washington, District of Columbia

13. Division of Renal Medicine, Department of Clinical Science, Intervention and Technology, Karolinska Institute, Stockholm, Sweden

Abstract

Inhalation of silica nanoparticles (SiNPs) released during the burning of sugarcane has been postulated to have a role in chronic kidney disease of unknown etiology (CKDu). We administered 200- and 300-nm amorphous SiNPs to rats by aspiration and observed kidney damage with tubular injury and inflammation that persisted even after stopping the SiNP exposure. These findings support the hypothesis that human exposure to SiNPs found in sugarcane ash could have a participatory role CKDu.

Funder

HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases

HHS | NIH | National Institute of Environmental Health Sciences

Publisher

American Physiological Society

Subject

Physiology

Link

https://journals.physiology.org/doi/pdf/10.1152/ajprenal.00021.2022

Reference55 articles.

1. Crystalline silica-induced leukotriene B4-dependent inflammation promotes lung tumour growth

2. The association between silica exposure and development of ANCA-associated vasculitis: Systematic review and meta-analysis