SLC41A1 knockout mice display normal magnesium homeostasis-Reference-Cited by-同舟云学术

SLC41A1 knockout mice display normal magnesium homeostasis

Published:2022-11-01 Issue:5 Volume:323 Page:F553-F563
ISSN:1931-857X
Container-title:American Journal of Physiology-Renal Physiology
language:en
Short-container-title:American Journal of Physiology-Renal Physiology

Author:

Ilenwabor Barnabas P.¹^ORCID,Franken Gijs A. C.¹^ORCID,Sponder Gerhard²,Bos Caro¹^ORCID,Racay Peter³⁴^ORCID,Kolisek Martin⁴,Hoenderop Joost G. J.¹^ORCID,de Baaij Jeroen H. F.¹^ORCID

Affiliation:

1. Department of Physiology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, The Netherlands

2. Institute of Veterinary Physiology, Freie Universität Berlin, Berlin, Germany

3. Department of Medical Biochemistry, Jessenius Faculty of Medicine, Comenius University in Bratislava, Martin, Slovakia

4. Biomedical Center Martin, Jessenius Faculty of Medicine, Comenius University in Bratislava, Martin, Slovakia

Abstract

SLC41A1 has been hypothesized to mediate Mg2+ extrusion in the distal convoluted tubule and thus regulate Mg2+ homeostasis. This study investigated the role of SLC41A1 in Mg2+ homeostasis in vivo using a transgenic mouse model. Our results demonstrate that SLC41A1 is not required to maintain normal Mg2+ balance in mice. We also show that SLC41A3 is more important than SLC41A1 in regulating systemic Mg2+ levels.

Funder

Niger Delta Development Commission

Nederlandse Organisatie voor Wetenschappelijk Onderzoek

Vedecká Grantová Agentúra MŠVVaŠ SR a SAV

Agentúra na Podporu Výskumu a Vývoja

Deutsche Forschungsgemeinschaft

Publisher

American Physiological Society

Subject

Physiology

Link

https://journals.physiology.org/doi/pdf/10.1152/ajprenal.00101.2022