Affiliation:
1. Gubra Aps, Horsholm, Denmark
Abstract
Translational animal models of diabetic kidney disease (DKD) are important tools in preclinical research and drug discovery. Here, we show that standard of care to control hypertension (lisinopril) and hyperglycemia (empagliflozin) improves kidney physiological and histopathological hallmarks in a mouse model of hypertension-accelerated progressive DKD. The findings substantiate hypertension and type 2 diabetes as essential factors in driving DKD progression, and provide proof-of-concept for probing novel drugs for potential nephroprotective efficacy in this model.
Publisher
American Physiological Society
Cited by
15 articles.
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