IL-1 receptor signaling in podocytes limits susceptibility to glomerular damage-Reference-Cited by-同舟云学术

IL-1 receptor signaling in podocytes limits susceptibility to glomerular damage

Published:2022-02-01 Issue:2 Volume:322 Page:F164-F174
ISSN:1931-857X
Container-title:American Journal of Physiology-Renal Physiology
language:en
Short-container-title:American Journal of Physiology-Renal Physiology

Author:

Ren Jiafa¹²,Lu Xiaohan¹,Hall Gentzon¹,Privratsky Jamie R.³^ORCID,Robson Matthew J.⁴,Blakely Randy D.⁵,Crowley Steven D.¹

Affiliation:

1. Division of Nephrology, Department of Medicine, Durham Veterans Affairs and Duke University Medical Centers, Durham, North Carolina

2. Department of Nephrology, The First Affiliated Hospital of Nanjing Medical University, Nanjing Medical University, Nanjing, People’s Republic of China

3. Department of Anesthesiology, Durham Veterans Affairs and Duke University Medical Centers, Durham, North Carolina

4. Division of Pharmaceutical Sciences, James L. Winkle College of Pharmacy, University of Cincinnati, Cincinnati, Ohio

5. Department of Biomedical Science, Charles E. Schmidt College of Medicine and FAU Brain Institute, Jupiter, Florida

Abstract

The present study establishes that activation of the receptor for interleukin-1 limits susceptibility to damage to the kidney glomerulus in preclinical mouse models by stimulating Akt signaling cascades inside the podocyte.

Funder

American Heart Association

HHS | NIH | National Heart, Lung, and Blood Institute

HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases

U.S. Department of Veterans Affairs

Publisher

American Physiological Society

Subject

Physiology

Link

https://journals.physiology.org/doi/pdf/10.1152/ajprenal.00353.2021

Reference48 articles.