Chronic environmental hypoxia attenuates innate immunity activation and renal injury in two CKD models-Reference-Cited by-同舟云学术

Chronic environmental hypoxia attenuates innate immunity activation and renal injury in two CKD models

Published:2023-09-01 Issue:3 Volume:325 Page:F283-F298
ISSN:1931-857X
Container-title:American Journal of Physiology-Renal Physiology
language:en
Short-container-title:American Journal of Physiology-Renal Physiology

Author:

Zambom Fernanda Florencia Fregnan¹^ORCID,Albino Amanda Helen¹^ORCID,Tessaro Helena Mendonça¹,Foresto-Neto Orestes²^ORCID,Malheiros Denise Maria Avancini Costa¹^ORCID,Saraiva Camara Niels Olsen¹²,Zatz Roberto¹^ORCID

Affiliation:

1. Renal Division, Department of Clinical Medicine, Faculty of Medicine, University of São Paulo, São Paulo, Brazil

2. Laboratory of Transplantation Immunobiology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil

Abstract

Hypoxia is regarded as a major pathogenic factor in chronic kidney disease (CKD). In disagreement with this view, we show here that sustained exposure to low ambient Po2 lessened kidney injury and inflammation in two CKD models: adenine (ADE) excess and chronic nitric oxide (NO) inhibition. Together with our previous findings in the remnant kidney, these observations indicate that local changes elicited by hypoxia may exert renoprotection in CKD, raising the prospect of novel therapeutic strategies for this disease.

Funder

Conselho Nacional de Desenvolvimento Científico e Tecnológico

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior

Fundação de Amparo à Pesquisa do Estado de São Paulo

Publisher

American Physiological Society

Subject

Physiology

Link

https://journals.physiology.org/doi/pdf/10.1152/ajprenal.00200.2022

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