K<sub>V</sub>7.1 channel blockade inhibits neonatal renal autoregulation triggered by a step decrease in arterial pressure-Reference-Cited by-同舟云学术

K_V7.1 channel blockade inhibits neonatal renal autoregulation triggered by a step decrease in arterial pressure

Published:2022-02-01 Issue:2 Volume:322 Page:F197-F207
ISSN:1931-857X
Container-title:American Journal of Physiology-Renal Physiology
language:en
Short-container-title:American Journal of Physiology-Renal Physiology

Author:

Peixoto-Neves Dieniffer¹,Kanthakumar Praghalathan¹^ORCID,Afolabi Jeremiah M.¹,Soni Hitesh¹,Buddington Randal K.²,Adebiyi Adebowale¹^ORCID

Affiliation:

1. Department of Physiology, University of Tennessee Health Science Center, Memphis, Tennessee

2. School of Health Studies, University of Memphis, Memphis, Tennessee

Abstract

KV7.1 is present in fetal pig kidneys as early as day 50 of gestation, and the level of expression remains the same up to postnatal day 21. KV7.1 is functionally expressed in neonatal pig renal vascular smooth muscle cells (SMCs). A decrease in arterial pressure up to 20 mmHg induces renal autoregulation in neonatal pigs. Although SMC KV7.1 does not control basal renal vascular resistance, its inhibition blunts neonatal renal autoregulation engendered by a step decrease in arterial pressure.

Funder

American Heart Association

HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases

Publisher

American Physiological Society

Subject

Physiology

Link

https://journals.physiology.org/doi/pdf/10.1152/ajprenal.00568.2020

Reference71 articles.

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