Nicotinic acetylcholine receptor agonist reduces acute lung injury after renal ischemia-reperfusion injury by acting on splenic macrophages in mice-Reference-Cited by-同舟云学术

Nicotinic acetylcholine receptor agonist reduces acute lung injury after renal ischemia-reperfusion injury by acting on splenic macrophages in mice

Published:2022-05-01 Issue:5 Volume:322 Page:F540-F552
ISSN:1931-857X
Container-title:American Journal of Physiology-Renal Physiology
language:en
Short-container-title:American Journal of Physiology-Renal Physiology

Author:

Goto Daiki¹,Nagata Soichiro¹,Naito Yoshitaka¹,Isobe Shinsuke¹,Iwakura Takamasa¹^ORCID,Fujikura Tomoyuki¹,Ohashi Naro¹,Kato Akihiko²,Miyajima Hiroaki¹,Sugimoto Ken¹,Yasuda Hideo¹^ORCID

Affiliation:

1. First Department of Medicine, Hamamatsu University School of Medicine, Hamamatsu, Japan

2. Division of Blood Purification, Hamamatsu University Hospital, Hamamatsu, Japan

Abstract

Acute lung injury associated with acute kidney injury contributes to high mortality. This study showed, for the first time, that nicotinic acetylcholine receptor agonists reduced circulating IL-6 and ALI after renal ischemia-reperfusion injury in mice. These effects of α7nAChR agonist were eliminated in both splenectomized and splenic macrophage (including systemic mononuclear phagocyte)-depleted mice but not alveolar macrophage-depleted mice. nAChR agonist could reduce ALI after AKI via splenic macrophages and provide a novel strategy in AKI.

Funder

MEXT | Japan Society for the Promotion of Science

Hamamatsu University School of Medicine

Publisher

American Physiological Society

Subject

Physiology

Link

https://journals.physiology.org/doi/pdf/10.1152/ajprenal.00334.2021

Reference61 articles.

1. Clinical Decision Support for In-Hospital AKI

2. Epidemiology of acute kidney injury in critically ill patients: the multinational AKI-EPI study