SGLT2 inhibition effect on salt-induced hypertension, RAAS, and Na<sup>+</sup> transport in Dahl SS rats-Reference-Cited by-同舟云学术

SGLT2 inhibition effect on salt-induced hypertension, RAAS, and Na⁺ transport in Dahl SS rats

Published:2022-06-01 Issue:6 Volume:322 Page:F692-F707
ISSN:1931-857X
Container-title:American Journal of Physiology-Renal Physiology
language:en
Short-container-title:American Journal of Physiology-Renal Physiology

Author:

Kravtsova Olha¹^ORCID,Bohovyk Ruslan¹,Levchenko Vladislav¹,Palygin Oleg²^ORCID,Klemens Christine A.¹³^ORCID,Rieg Timo¹⁴³^ORCID,Staruschenko Alexander¹⁴³^ORCID

Affiliation:

1. Department of Molecular Pharmacology and Physiology, University of South Florida, Tampa, Florida

2. Department of Medicine, Medical University of South Carolina, Charleston, South Carolina

3. Hypertension and Kidney Research Center, University of South Florida, Tampa, Florida

4. James A. Haley Veterans’ Hospital, Tampa, Florida

Abstract

The present study indicates that Na+-glucose cotransporter-2 (SGLT2) inhibition in a nondiabetic model of salt-sensitive hypertension blunts the development and magnitude of salt-induced hypertension. Chronic inhibition of SGLT2 increases glucose and Na+ excretion without secondary effects on the expression and function of other Na+ transporters and channels along the nephron and hormone levels in the renin-angiotensin-aldosterone system. These data provide novel insights into the effects of SGLT2 inhibitors and their potential use in hypertension.

Funder

American Heart Association

American Physiological Society

HHS | NIH | National Heart, Lung, and Blood Institute

HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases

U.S. Department of Veterans Affairs

Publisher

American Physiological Society

Subject

Physiology

Link

https://journals.physiology.org/doi/pdf/10.1152/ajprenal.00053.2022