Experimental nephrotic syndrome leads to proteolytic activation of the epithelial Na+ channel in the mouse kidney-Reference-Cited by-同舟云学术

Experimental nephrotic syndrome leads to proteolytic activation of the epithelial Na+ channel in the mouse kidney

Published:2021-10-01 Issue:4 Volume:321 Page:F480-F493
ISSN:1931-857X
Container-title:American Journal of Physiology-Renal Physiology
language:en
Short-container-title:American Journal of Physiology-Renal Physiology

Author:

Bohnert Bernhard N.¹²³,Essigke Daniel¹,Janessa Andrea¹,Schneider Jonas C.¹,Wörn Matthias¹,Kalo M. Zaher¹,Xiao Mengyun¹,Kong Lingsi¹,Omage Kingsley¹,Hennenlotter Jörg⁴,Amend Bastian⁴,Birkenfeld Andreas L.¹²³,Artunc Ferruh¹²³^ORCID

Affiliation:

1. Division of Endocrinology, Diabetology and Nephrology, Department of Internal Medicine, University Hospital Tübingen, Tübingen, Germany

2. Institute of Diabetes Research and Metabolic Diseases, Helmholtz Center Munich, University Tübingen, Tübingen, Germany

3. German Center for Diabetes Research, University Tübingen, Tübingen, Germany

4. Department of Urology, University Hospital Tübingen, Tübingen, Germany

Abstract

This study demonstrates that murine experimental nephrotic syndrome leads to aprotinin-sensitive proteolytic activation of the epithelial Na+ channel at both the α- and γ-subunit, most likely by urinary serine protease activity or proteasuria.

Funder

Deutsche Forschungsgemeinschaft

Publisher

American Physiological Society

Subject

Physiology

Link

https://journals.physiology.org/doi/pdf/10.1152/ajprenal.00199.2021

Reference44 articles.

1. Activation of the Epithelial Sodium Channel (ENaC) by Serine Proteases

2. Regulating ENaC’s gate

3. The Epithelial Na+ Channel Is Inhibited by a Peptide Derived from Proteolytic Processing of Its α Subunit