NK1.1− natural killer T cells upregulate interleukin-17 expression in experimental lupus nephritis-Reference-Cited by-同舟云学术

NK1.1− natural killer T cells upregulate interleukin-17 expression in experimental lupus nephritis

Published:2021-05-01 Issue:5 Volume:320 Page:F772-F788
ISSN:1931-857X
Container-title:American Journal of Physiology-Renal Physiology
language:en
Short-container-title:American Journal of Physiology-Renal Physiology

Author:

An Jung Nam¹,Ryu Seungwon²,Kim Yong Chul³,Yoo Kyung Don⁴^ORCID,Lee Jangwook³,Kim Hye Young²⁵,Lee Hajeong³,Lee Jung Pyo⁶⁷,Lee Jae Wook⁸⁹,Jeon Un Sil³¹⁰,Kim Dong Ki³⁷,Kim Yon Su³⁷,Yang Seung Hee⁹¹¹

Affiliation:

1. Department of Internal Medicine, Hallym University Sacred Heart Hospital, Anyang, Korea

2. Laboratory of Mucosal Immunology, Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul, Korea

3. Department of Internal Medicine, Seoul National University Hospital, Seoul, Korea

4. Department of Internal Medicine, Ulsan University Hospital, Ulsan, Korea

5. Institute of Allergy and Clinical Immunology, Seoul National University Medical Research Center, Seoul, Korea

6. Department of Internal Medicine, Seoul National University Boramae Medical Center, Seoul, Korea

7. Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea

8. Nephrology Clinic, National Cancer Center, Goyang, Korea

9. Kidney Research Institute, Seoul National University, Seoul, Korea

10. Division of Nephrology, Department of Internal Medicine, Sheikh Khalifa Specialty Hospital, Ras Al Khaimah, United Arab Emirates

11. Biomedical Research Institute, Seoul National University Hospital, Seoul, Korea

Abstract

This study makes a significant contribution to the literature because our results indicate that IL-17 is upregulated in lupus nephritis and that natural killer T (NKT) cells are involved in its pathogenesis. Activation of NKT cells regulates IL-17-related immune responses, both systemically and in the kidney, and this mainly involves NK1.1− NKT cells. Furthermore, IL-17-secreting NK1.1− NKT cells could serve as a diagnostic and therapeutic target for lupus nephritis.

Funder

Korean Society of Nephrology

National Research Foundation of Korea

Publisher

American Physiological Society

Subject

Physiology

Link

https://journals.physiology.org/doi/pdf/10.1152/ajprenal.00252.2020

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