Local and downstream actions of proximal tubule angiotensin II signaling on Na+ transporters in the mouse nephron-Reference-Cited by-同舟云学术

Local and downstream actions of proximal tubule angiotensin II signaling on Na+ transporters in the mouse nephron

Published:2021-07-01 Issue:1 Volume:321 Page:F69-F81
ISSN:1931-857X
Container-title:American Journal of Physiology-Renal Physiology
language:en
Short-container-title:American Journal of Physiology-Renal Physiology

Author:

Nelson Jonathan W.¹^ORCID,McDonough Alicia A.²^ORCID,Xiang Zhidan³,Ralph Donna L.²,Robertson Joshua A.¹,Giani Jorge F.⁴^ORCID,Bernstein Kenneth E.⁴,Gurley Susan B.¹

Affiliation:

1. Division of Nephrology and Hypertension, Department of Medicine, Oregon Health and Science University, Portland, Oregon

2. Department of Physiology and Neuroscience, Keck School of Medicine, University of Southern California, Los Angeles, California

3. Wake Forest University, Winston-Salem, North Carolina

4. Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, California

Abstract

Our study defines a novel role for proximal tubule angiotensin receptors in regulating the abundance of Na+ transporters throughout the nephron, thereby contributing to the integrated control of fluid balance in vivo.

Funder

The Collins Medical Trust

American Heart Association

HHS | NIH | National Heart, Lung, and Blood Institute

HHS | NIH | National Institute of Allergy and Infectious Diseases

HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases

Publisher

American Physiological Society

Subject

Physiology

Link

https://journals.physiology.org/doi/pdf/10.1152/ajprenal.00014.2021