Functional characterization of ion channels expressed in kidney organoids derived from human induced pluripotent stem cells-Reference-Cited by-同舟云学术

Functional characterization of ion channels expressed in kidney organoids derived from human induced pluripotent stem cells

Published:2022-10-01 Issue:4 Volume:323 Page:F479-F491
ISSN:1931-857X
Container-title:American Journal of Physiology-Renal Physiology
language:en
Short-container-title:American Journal of Physiology-Renal Physiology

Author:

Montalbetti Nicolas¹^ORCID,Przepiorski Aneta J.²^ORCID,Shi Shujie¹^ORCID,Sheng Shaohu¹^ORCID,Baty Catherine J.¹,Maggiore Joseph C.²^ORCID,Carattino Marcelo D.¹³^ORCID,Vanichapol Thitinee⁴,Davidson Alan J.⁴^ORCID,Hukriede Neil A.²,Kleyman Thomas R.¹³⁵^ORCID

Affiliation:

1. Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania

2. Department of Developmental Biology, University of Pittsburgh, Pittsburgh, Pennsylvania

3. Department of Cell Biology, University of Pittsburgh, Pittsburgh, Pennsylvania

4. Department of Molecular Medicine and Pathology, School of Medical Sciences, University of Auckland, Auckland, New Zealand

5. Department of Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh, Pennsylvania

Abstract

Our results show that human kidney organoids express key K+ and Na+ channels that are expressed on the apical membranes of cells in the aldosterone-sensitive distal nephron, including the large-conductance Ca2+-activated K+ channel, renal outer medullary K+ channel, and epithelial Na+ channel.

Funder

HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases

Urology Care Foundation

ASN Foundation for Kidney Research

HHS | NIH | National Heart, Lung, and Blood Institute

HHS | NIH | NIH Office of the Director

Publisher

American Physiological Society

Subject

Physiology

Link

https://journals.physiology.org/doi/pdf/10.1152/ajprenal.00365.2021