Farnesoid X receptor prevents neutrophil extracellular traps via reduced sphingosine-1-phosphate in chronic kidney disease-Reference-Cited by-同舟云学术

Farnesoid X receptor prevents neutrophil extracellular traps via reduced sphingosine-1-phosphate in chronic kidney disease

Published:2023-12-01 Issue:6 Volume:325 Page:F792-F810
ISSN:1931-857X
Container-title:American Journal of Physiology-Renal Physiology
language:en
Short-container-title:American Journal of Physiology-Renal Physiology

Author:

Jones Bryce A.¹^ORCID,Myakala Komuraiah²^ORCID,Guha Mahilan²^ORCID,Davidson Shania³,Adapa Sharmila²,Lopez Santiago Isabel²^ORCID,Schaffer Isabel²^ORCID,Yue Yang⁴,Allegood Jeremy C.⁴,Cowart L. Ashley⁴,Wang Xiaoxin X.²^ORCID,Rosenberg Avi Z.⁵,Levi Moshe²^ORCID

Affiliation:

1. Department of Pharmacology and Physiology, Georgetown University, Washington, District of Columbia, United States

2. Department of Biochemistry and Molecular and Cellular Biology, Georgetown University, Washington, District of Columbia, United States

3. Department of Biology, Howard University, Washington, District of Columbia, United States

4. Department of Biochemistry and Molecular Biology, Virginia Commonwealth University, Richmond, Virginia, United States

5. Department of Pathology, Johns Hopkins School of Medicine, Baltimore, Maryland, United States

Abstract

Many preclinical studies have shown that the farnesoid X receptor (FXR) reduces renal inflammation, but the mechanism is poorly understood. This report identifies FXR as a novel regulator of neutrophilic inflammation and NETosis via the inhibition of sphingosine-1-phosphate signaling. Additionally, NETosis severity in human Alport kidney biopsies correlates with clinical markers of kidney disease. A better understanding of this signaling axis may lead to novel treatments that prevent renal inflammation and chronic kidney disease.

Funder

HHS | NIH | National Cancer Institute

HHS | NIH | National Center for Advancing Translational Sciences

HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases

Publisher

American Physiological Society

Subject

Physiology

Link

https://journals.physiology.org/doi/pdf/10.1152/ajprenal.00292.2023

Reference77 articles.

1. Immune cell dysfunction and inflammation in end-stage renal disease

2. Immunometabolic rewiring of tubular epithelial cells in kidney disease

3. Inflammatory processes in renal fibrosis

4. 2,8-Dihydroxyadenine lithiasis

5. Kidney Disease in Adenine Phosphoribosyltransferase Deficiency

Cited by 2 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Nicotinamide riboside activates renal metabolism and protects the kidney in a model of Alport syndrome;2024-02-29

2. Neutrophils - Biology and Diversity;Nephrology Dialysis Transplantation;2023-12-19