COP9 signalosome deletion promotes renal injury and distal convoluted tubule remodeling-Reference-Cited by-同舟云学术

COP9 signalosome deletion promotes renal injury and distal convoluted tubule remodeling

Published:2022-07-01 Issue:1 Volume:323 Page:F4-F19
ISSN:1931-857X
Container-title:American Journal of Physiology-Renal Physiology
language:en
Short-container-title:American Journal of Physiology-Renal Physiology

Author:

Cornelius Ryan J.¹^ORCID,Nelson Jonathan W.¹^ORCID,Su Xiao-Tong¹^ORCID,Yang Chao-Ling¹,Ellison David H.¹²^ORCID

Affiliation:

1. Division of Nephrology and Hypertension, Department of Medicine, Oregon Health and Science University, Portland, Oregon

2. Veterans Affairs Portland Health Care System, Portland, Oregon

Abstract

Cullin 3 (CUL3) targets with-no-lysine-kinase 4 (WNK4), which activates Na+-Cl− cotransporter (NCC) in the distal convoluted tubule (DCT) of the kidney. Renal-specific genetic deletion of the constitutive photomorphogenesis 9 signalosome, an upstream regulator of CUL3, resulted in a reduction of NCC due to DCT hypoplasia, which coincided with cortical kidney injury. The data indicate that nephron-specific disruption of the cullin-RING ligase system results in a complex progression of tubule injury leading to hypoplasia of the DCT.

Funder

Fondation Leducq

HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases

Publisher

American Physiological Society

Subject

Physiology

Link

https://journals.physiology.org/doi/pdf/10.1152/ajprenal.00436.2021

Reference44 articles.

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