JAK inhibition during the early phase of SARS-CoV-2 infection worsens kidney injury by suppressing endogenous antiviral activity in mice-Reference-Cited by-同舟云学术

JAK inhibition during the early phase of SARS-CoV-2 infection worsens kidney injury by suppressing endogenous antiviral activity in mice

Published:2024-06-01 Issue:6 Volume:326 Page:F931-F941
ISSN:1931-857X
Container-title:American Journal of Physiology-Renal Physiology
language:en
Short-container-title:American Journal of Physiology-Renal Physiology

Author:

Sakai Hibiki¹,Kamuro Hiroyasu¹,Tokunoh Nagisa²³,Izawa Takeshi⁴,Tamiya Shigeyuki²⁵,Yamamoto Ayaha¹,Tanaka Shota¹^ORCID,Okuzaki Daisuke⁶^ORCID,Ono Chikako⁷⁸,Matsuura Yoshiharu⁷⁸⁹,Okada Yoshiaki¹⁸^ORCID,Yoshioka Yasuo²³⁸⁹¹⁰,Fujio Yasushi¹⁸¹⁰^ORCID,Obana Masanori¹⁸¹⁰¹¹¹²^ORCID

Affiliation:

1. Laboratory of Clinical Science and Biomedicine, Graduate School of Pharmaceutical Sciences, Osaka University, Osaka, Japan

2. Vaccine Creation Group, BIKEN Innovative Vaccine Research Alliance Laboratories, Research Institute for Microbial Diseases, Osaka University, Osaka, Japan

3. Research Foundation for Microbial Diseases, Osaka University, Osaka, Japan

4. Laboratory of Veterinary Pathology, Osaka Metropolitan University Graduate School of Veterinary Science, Osaka, Japan

5. Department of Microbiology and Immunology, School of Pharmaceutical Sciences, Wakayama Medical University, Wakayama, Japan

6. Genome Information Research Center, Research Institute for Microbial Diseases, Osaka University, Osaka, Japan

7. Laboratory of Virus Control, Research Institute for Microbial Diseases, Osaka University, Osaka, Japan

8. Center for Infectious Disease Education and Research, Osaka University, Osaka, Japan

9. Center for Advanced Modalities and DDS, Osaka University, Osaka, Japan

10. Institute for Open and Transdisciplinary Research Initiatives, Osaka University, Osaka, Japan

11. Global Center for Medical Engineering and Informatics, Osaka University, Osaka, Japan

12. Radioisotope Research Center, Institute for Radiation Sciences, Osaka University, Osaka, Japan

Abstract

Patients frequently present with acute kidney injury or abnormal urinary findings after severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Here, we investigated how the kidneys respond during SARS-CoV-2 infection using a murine coronavirus disease 2019 (COVID-19) model and showed that Janus kinase-mediated endogenous antiviral activity protects against kidney injury in the early phase of SARS-CoV-2 infection. These findings provide valuable insights into the renal pathophysiology of COVID-19.

Funder

Hoansha Foundation

Japan Agency for Medical Research and Development

Japanese Association of Dialysis Physicians

Mochida Memorial Foundation for Medical and Pharmaceutical Research

Nippon Foundation

Publisher

American Physiological Society

Link

https://journals.physiology.org/doi/pdf/10.1152/ajprenal.00011.2024

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