Amiloride lowers plasma TNF and interleukin-6 but not interleukin-17A in patients with hypertension and type 2 diabetes-Reference-Cited by-同舟云学术

Amiloride lowers plasma TNF and interleukin-6 but not interleukin-17A in patients with hypertension and type 2 diabetes

Published:2024-07-01 Issue:1 Volume:327 Page:F37-F48
ISSN:1931-857X
Container-title:American Journal of Physiology-Renal Physiology
language:en
Short-container-title:American Journal of Physiology-Renal Physiology

Author:

Thangaraj Sai Sindhu¹^ORCID,Oxlund Christina S.²^ORCID,Andersen Henrik¹,Svenningsen Per¹^ORCID,Stubbe Jane¹^ORCID,Palarasah Yaseelan³,Fonseca Micaella Pereira Da¹,Ketelhuth Daniel F. J.¹,Enggaard Camilla¹^ORCID,Hansen Maria Høj¹,Henriksen Jan Erik⁴^ORCID,Jacobsen Ib Abildgaard⁵,Jensen Boye L.¹^ORCID

Affiliation:

1. Department of Cardiovascular and Renal Research, Institute for Molecular Medicine, University of Southern Denmark, Odense, Denmark

2. Department of Cardiology, Hospital of Southwest Jutland, Esbjerg, Denmark

3. Department of Cancer and Inflammation Research, Institute for Molecular Medicine, University of Southern Denmark, Odense, Denmark

4. Steno Diabetes Center Odense, Odense, Denmark

5. Research Unit for Cardiovascular and Metabolic Prevention, Department of Endocrinology, Odense University Hospital, Odense, Denmark

Abstract

ENaC activity may contribute to macrophage-derived cytokine release, since amiloride exerts anti-inflammatory effects by suppression of TNF and IL-6 cytokines in patients with resistant hypertension and type 2 diabetes and in THP-1-derived macrophages in vitro.

Funder

Region Syddanmark

Novo Nordisk

Karen Elise Jensens Fond

Danmarks Frie Forskningsfond

Publisher

American Physiological Society

Link

https://journals.physiology.org/doi/pdf/10.1152/ajprenal.00268.2023

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