Role of the CDKL1-SOX11 signaling axis in acute kidney injury-Reference-Cited by-同舟云学术

Role of the CDKL1-SOX11 signaling axis in acute kidney injury

Published:2024-09-01 Issue:3 Volume:327 Page:F426-F434
ISSN:1931-857X
Container-title:American Journal of Physiology-Renal Physiology
language:en
Short-container-title:American Journal of Physiology-Renal Physiology

Author:

Silvaroli Josie A.¹^ORCID,Martinez Gabriela V.²,Vanichapol Thitinee³^ORCID,Davidson Alan J.³^ORCID,Zepeda-Orozco Diana²^ORCID,Pabla Navjot S.¹,Kim Ji Young¹^ORCID

Affiliation:

1. Division of Pharmaceutics and Pharmacology, College of Pharmacy and Comprehensive Cancer Center, Ohio State University, Columbus, Ohio, United States

2. Kidney and Urinary Tract Research Center, The Abigail Wexner Research Institute, Nationwide Children’s Hospital, Columbus, Ohio, United States

3. Department of Molecular Medicine and Pathology, University of Auckland, Auckland, New Zealand

Abstract

Identifying and targeting pathogenic protein kinases holds potential for drug discovery in treating acute kidney injury. Our study, using novel germline knockout mice, revealed that Cdkl1 kinase deficiency does not affect mouse viability but provides protection against acute kidney injury. This underscores the importance of Cdkl1 kinase in kidney injury and supports the development of targeted small-molecule inhibitors as potential therapeutics.

Funder

American Heart Association

HHS | NIH | NIDDK | Division of Diabetes, Endocrinology, and Metabolic Diseases

LouLou Foundation

OSU | Graduate School, Ohio State University

Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute

Publisher

American Physiological Society

Link

https://journals.physiology.org/doi/pdf/10.1152/ajprenal.00147.2024

Reference54 articles.

1. Acute Kidney Injury

2. Raising awareness of acute kidney injury: a global perspective of a silent killer

3. Acute kidney injury

4. Acute kidney injury: what's the prognosis?