Fibroblast growth factor 23 leads to endolysosomal routing of the renal phosphate cotransporters NaPi-IIa and NaPi-IIc in vivo-Reference-Cited by-同舟云学术

Fibroblast growth factor 23 leads to endolysosomal routing of the renal phosphate cotransporters NaPi-IIa and NaPi-IIc in vivo

Published:2021-12-01 Issue:6 Volume:321 Page:F785-F798
ISSN:1931-857X
Container-title:American Journal of Physiology-Renal Physiology
language:en
Short-container-title:American Journal of Physiology-Renal Physiology

Author:

Küng Catharina J.¹,Haykir Betül¹,Schnitzbauer Udo¹,Egli-Spichtig Daniela¹,Hernando Nati¹,Wagner Carsten A.¹^ORCID

Affiliation:

1. Institute of Physiology, University of Zurich and National Center of Competence in Research Kidney.CH, Zurich, Switzerland

Abstract

The hormone fibroblast growth factor 23 (FGF23) controls phosphate homeostasis by regulating renal phosphate excretion. FGF23 acts on several phosphate transporters in the kidney. Here, we define the time course of this action and demonstrate how phosphate transporters NaPi-IIa and NaPi-IIc are degraded.

Funder

Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung

Publisher

American Physiological Society

Subject

Physiology

Link

https://journals.physiology.org/doi/pdf/10.1152/ajprenal.00250.2021

Reference57 articles.

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4. 1α,25-Dihydroxyvitamin D3upregulates FGF23 gene expression in bone: the final link in a renal-gastrointestinal-skeletal axis that controls phosphate transport

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