Overexpressed angiotensin-converting enzyme in neutrophils suppresses glomerular damage in crescentic glomerulonephritis-Reference-Cited by-同舟云学术

Overexpressed angiotensin-converting enzyme in neutrophils suppresses glomerular damage in crescentic glomerulonephritis

Published:2022-10-01 Issue:4 Volume:323 Page:F411-F424
ISSN:1931-857X
Container-title:American Journal of Physiology-Renal Physiology
language:en
Short-container-title:American Journal of Physiology-Renal Physiology

Author:

Saito Suguru¹,Tatsumoto Narihito²,Cao Duo-Yao¹,Nosaka Nobuyuki³,Nishi Hiroshi⁴,Leal Daniel N.²,Bernstein Ellen¹,Shimada Kenichi³⁵,Arditi Moshe³⁵,Bernstein Kenneth E.²¹,Yamashita Michifumi²^ORCID

Affiliation:

1. Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, California

2. Department of Pathology and Laboratory Medicine, Cedars-Sinai Medical Center, Los Angeles, California

3. Division of Infectious Diseases and Immunology, Department of Pediatrics, Cedars-Sinai Medical Center, Los Angeles, California

4. Division of Nephrology and Endocrinology, The University of Tokyo Graduate School of Medicine, Tokyo, Japan

5. Department of Biomedical Sciences, Infectious and Immunologic Diseases Research Center, Cedars-Sinai Medical Center, Los Angeles, California

Abstract

We studied immune complex (IC)-mediated crescentic glomerulonephritis in NeuACE mice that overexpress ACE only in neutrophils. Such mice show no significant defects in humoral immunity but strongly resist nephrotoxic serum nephritis (less proteinuria, milder histological damage, reduced IC deposits, and more glomerular neutrophils). NeuACE neutrophils enhanced IC uptake via increased surface expression of CR1/2 and FcgRII/III, as well as elevated serum complement C3b. These results suggest neutrophil ACE as a novel approach to reducing glomerulonephritis.

Funder

American Heart Association

HHS | NIH | National Center for Advancing Translational Sciences

HHS | NIH | National Heart, Lung, and Blood Institute

HHS | NIH | National Institute of Allergy and Infectious Diseases

Publisher

American Physiological Society

Subject

Physiology

Link

https://journals.physiology.org/doi/pdf/10.1152/ajprenal.00067.2022

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