Therapeutic α-1-microglobulin ameliorates kidney ischemia-reperfusion injury-Reference-Cited by-同舟云学术

Therapeutic α-1-microglobulin ameliorates kidney ischemia-reperfusion injury

Published:2024-07-01 Issue:1 Volume:327 Page:F103-F112
ISSN:1931-857X
Container-title:American Journal of Physiology-Renal Physiology
language:en
Short-container-title:American Journal of Physiology-Renal Physiology

Author:

Burmakin Mikhail¹²^ORCID,Gilmour Peter S.²^ORCID,Gram Magnus³⁴⁵,Shushakova Nelli⁶⁷,Sandoval Ruben M.⁸,Molitoris Bruce A.⁸^ORCID,Larsson Tobias E.²⁹

Affiliation:

1. Division of Pathology, Department of Laboratory Medicine, Karolinska Institute, Huddinge, Sweden

2. Guard Therapeutics International AB, Stockholm, Sweden

3. Pediatrics, Department of Clinical Sciences Lund, Lund University, Lund, Sweden

4. Department of Neonatology, Skåne University Hospital, Lund, Sweden

5. Biofilms – Research Center for Biointerfaces, Department of Biomedical Science, Faculty of Health and Society, Malmö University, Malmö, Sweden

6. Renal Disease and Transplantation, Phenos GmbH, Hannover, Germany

7. Department of Nephrology, Hannover Medical School, Hannover, Germany

8. Division of Nephrology, Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana, United States

9. Division of Nephrology, Department of Clinical Science, Intervention and Technology, Karolinska Institutet, Huddinge, Sweden

Abstract

A therapeutic A1M protein variant (RMC-035) is currently in phase 2 clinical development for renal protection in patients undergoing open-chest cardiac surgery. It targets several key pathways underlying kidney injury in this patient group, including oxidative stress, heme toxicity, and mitochondrial dysfunction. RMC-035 is rapidly eliminated from plasma, distributing to kidney proximal tubules, and demonstrates dose-dependent efficacy in numerous models of ischemia-reperfusion injury, particularly when administered before ischemia. These results support its continued clinical evaluation.

Publisher

American Physiological Society

Link

https://journals.physiology.org/doi/pdf/10.1152/ajprenal.00067.2024

Reference42 articles.

1. Therapeutic translation in acute kidney injury: the epithelial/endothelial axis

2. World Incidence of AKI: A Meta-Analysis

Acute kidney injury after cardiac surgery: prevalence, impact and management challenges