Sex-disaggregated analysis of acute kidney injury in hospitalized children with sickle cell anemia in Uganda-Reference-Cited by-同舟云学术

Sex-disaggregated analysis of acute kidney injury in hospitalized children with sickle cell anemia in Uganda

Published:2024-08-01 Issue:2 Volume:327 Page:F304-F313
ISSN:1931-857X
Container-title:American Journal of Physiology-Renal Physiology
language:en
Short-container-title:American Journal of Physiology-Renal Physiology

Author:

Weckman Andrea¹,McDonald Chloe R.²,Naggayi Shubaya K.³,Soranno Danielle E.⁴⁵^ORCID,Conroy Andrea L.³⁶^ORCID,Batte Anthony³⁷

Affiliation:

1. Michael G. DeGroote School of Medicine, McMaster University, Hamilton, Ontario, Canada

2. Sandra A. Rotman Laboratories, Sandra Rotman Centre for Global Health, University Health Network-Toronto General Hospital, Toronto, Ontario, Canada

3. Global Health Uganda Research Collaboration, Kampala, Uganda

4. Department of Pediatric Nephrology, Indiana University School of Medicine, Indianapolis, Indiana, United States

5. Department of Bioengineering, Purdue University, West Lafayette, Indiana, United States

6. Ryan White Center for Pediatric Infectious Disease and Global Health, Department of Pediatrics, Indiana University School of Medicine, Indianapolis, Indiana, United States

7. Child Health and Development Centre, College of Health Sciences, Makerere University, Kampala, Uganda

Abstract

In this study, we report an increased risk of developing acute kidney injury (AKI) during hospitalization, worsening AKI, and death among females with sickle cell anemia (SCA) hospitalized with an acute pain crisis compared with males. The sex differences in AKI were not explained by socioeconomic differences, severity of pain, or disease severity among females compared with males. Together, these data suggest that female children with SCA may be at increased risk of AKI.

Funder

HHS | NIH | Fogarty International Center

HHS | National Institutes of Health

Publisher

American Physiological Society

Link

https://journals.physiology.org/doi/pdf/10.1152/ajprenal.00385.2023

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