Choline supplementation attenuates experimental sepsis-associated acute kidney injury-Reference-Cited by-同舟云学术

Choline supplementation attenuates experimental sepsis-associated acute kidney injury

Published:2022-09-01 Issue:3 Volume:323 Page:F255-F271
ISSN:1931-857X
Container-title:American Journal of Physiology-Renal Physiology
language:en
Short-container-title:American Journal of Physiology-Renal Physiology

Author:

Hasson Denise C.¹,Watanabe-Chailland Miki²,Romick-Rosendale Lindsey²,Koterba Adeleine¹,Miner Dashiell S.¹,Lahni Patrick¹^ORCID,Ma Qing³,Goldstein Stuart L.³⁴,Devarajan Prasad³⁴^ORCID,Standage Stephen W.¹⁴^ORCID

Affiliation:

1. Division of Critical Care Medicine, Cincinnati Children’s Hospital Medical Center, Cincinnati, Ohio

2. Division of Pathology and Laboratory Medicine, Cincinnati Children’s Hospital Medical Center, Cincinnati, Ohio

3. Division of Nephrology and Hypertension, Cincinnati Children’s Hospital Medical Center, Cincinnati, Ohio

4. Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio

Abstract

Altered choline metabolism plays a role in both human and murine sepsis-associated acute kidney injury (SA-AKI), and choline administration in experimental SA-AKI improved renal function. These findings indicate that 1) mouse models can help interrogate clinically relevant mechanisms and 2) choline supplementation may ameliorate human SA-AKI. Future research will investigate clinically the impact of choline supplementation on human renal function in sepsis and, using model systems, how choline mediates its effects.

Funder

HHS | NIH | National Heart, Lung, and Blood Institute

HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases

HHS | NIH | National Institute of General Medical Sciences

Publisher

American Physiological Society

Subject

Physiology

Link

https://journals.physiology.org/doi/pdf/10.1152/ajprenal.00033.2022

Reference71 articles.

1. Epidemiology of Acute Kidney Injury in Critically Ill Children and Young Adults

2. Septic Acute Kidney Injury in Critically Ill Patients: Clinical Characteristics and Outcomes

3. Acute Renal Failure in Patients with Sepsis in a Surgical ICU: Predictive Factors, Incidence, Comorbidity, and Outcome

4. Early acute kidney injury and sepsis: a multicentre evaluation

5. A Prospective International Multicenter Study of AKI in the Intensive Care Unit

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