Expression and function of human ribonuclease 4 in the kidney and urinary tract-Reference-Cited by-同舟云学术

Expression and function of human ribonuclease 4 in the kidney and urinary tract

Published:2021-05-01 Issue:5 Volume:320 Page:F972-F983
ISSN:1931-857X
Container-title:American Journal of Physiology-Renal Physiology
language:en
Short-container-title:American Journal of Physiology-Renal Physiology

Author:

Bender Kristin¹²,Schwartz Laura L.¹²,Cohen Ariel¹³,Vasquez Claudia Mosquera¹²,Murtha Matthew J.¹⁴,Eichler Tad¹²,Thomas Jason P.¹⁵,Jackson Ashley¹²⁴⁵,Spencer John David¹²⁴⁵^ORCID

Affiliation:

1. Nephrology and Urology Research Affinity Group, Nationwide Children’s Hospital, Columbus, Ohio

2. The Abigail Wexner Research Institute at Nationwide Children’s Hospital, Center for Clinical and Translational Research, Columbus, Ohio

3. The University of Toledo College of Medicine and Life Sciences, Toledo, Ohio

4. The Ohio State University College of Medicine, Columbus, Ohio

5. Division of Nephrology, Department of Pediatrics, Nationwide Children’s Hospital, Columbus, Ohio

Abstract

Ribonuclease 4 (RNase 4) is a newly identified host defense peptide in the human kidney and bladder. RNase 4 kills uropathogenic Escherichia coli (UPEC) and multidrug-resistant UPEC. RNase 4 prevents invasive UPEC infection and suppressed RNase 4 expression may be a risk factor for more severe or recurrent urinary tract infection.

Funder

HHS | National Institutes of Health

Publisher

American Physiological Society

Subject

Physiology

Link

https://journals.physiology.org/doi/pdf/10.1152/ajprenal.00592.2020

Reference66 articles.

1. The epidemiology of urinary tract infection

2. Recurring urinary tract infection: incidence and risk factors.

3. Health care-associated infections – an overview