Parental obesity predisposes offspring to kidney dysfunction and increased susceptibility to ischemia-reperfusion injury in a sex-dependent manner-Reference-Cited by-同舟云学术

Parental obesity predisposes offspring to kidney dysfunction and increased susceptibility to ischemia-reperfusion injury in a sex-dependent manner

Published:2024-05-01 Issue:5 Volume:326 Page:F727-F736
ISSN:1931-857X
Container-title:American Journal of Physiology-Renal Physiology
language:en
Short-container-title:American Journal of Physiology-Renal Physiology

Author:

do Carmo Jussara M.¹^ORCID,Hall John E.¹,Dai Xuemei¹,Aitkens Nikaela¹^ORCID,Larson Kylie¹,Luna-Suarez Emilio M.¹,Wang Zhen¹^ORCID,Omoto Ana C. M.¹^ORCID,Mouton Alan¹^ORCID,Li Xuan¹^ORCID,Furukawa Luzia N. S.²^ORCID,Woronik Viktoria²,da Silva Alexandre A.¹^ORCID

Affiliation:

1. Department of Physiology and Biophysics, Mississippi Center for Obesity Research, Cardiorenal and Metabolic Diseases Research Center, University of Mississippi Medical Center, Jackson, Mississippi, United States

2. Laboratory of Renal Pathophysiology, Department of Internal Medicine, University of Sao Paulo, Sao Paulo, Brazil

Abstract

Offspring from obese parents are more susceptible to kidney injury and worse outcomes following an acute ischemia-reperfusion insult. Male, but not female, offspring from obese parents exhibit increased blood pressure early in life. Female offspring are partially protected against major kidney injury induced by ischemia-reperfusion.

Funder

HHS | NIH | NIDDK | Division of Diabetes, Endocrinology, and Metabolic Diseases

HHS | NIH | National Heart, Lung, and Blood Institute

HHS | NIH | National Institute of General Medical Sciences

Publisher

American Physiological Society

Link

https://journals.physiology.org/doi/pdf/10.1152/ajprenal.00294.2023

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