Renal mitochondrial dysfunction in ovine experimental sepsis-associated acute kidney injury-Reference-Cited by-同舟云学术

Renal mitochondrial dysfunction in ovine experimental sepsis-associated acute kidney injury

Published:2023-06-01 Issue:6 Volume:324 Page:F571-F580
ISSN:1931-857X
Container-title:American Journal of Physiology-Renal Physiology
language:en
Short-container-title:American Journal of Physiology-Renal Physiology

Author:

Luther Tomas¹^ORCID,Bülow-Anderberg Sara¹^ORCID,Persson Patrik²^ORCID,Franzén Stephanie¹^ORCID,Skorup Paul³^ORCID,Wernerson Annika⁴,Hultenby Kjell⁵,Palm Fredrik²,Schiffer Tomas A.⁶^ORCID,Frithiof Robert¹^ORCID

Affiliation:

1. Department of Surgical Sciences, Anesthesiology and Intensive Care, Uppsala University, Uppsala, Sweden

2. Section of Integrative Physiology, Department of Medical Cell Biology, Uppsala University, Uppsala, Sweden

3. Section of Infectious Diseases, Department of Medical Sciences, Uppsala University, Uppsala, Sweden

4. Division of Renal Medicine, Department of Clinical Science, Intervention and Technology, Karolinska Institutet, Stockholm, Sweden

5. Division of Biomolecular and Cellular Medicine, Department of Laboratory Medicine, Karolinska Institutet, Stockholm, Sweden

6. Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden

Abstract

We studied the function of renal cortical mitochondria in relation to oxygen consumption in an ovine model of sepsis with acute kidney injury. We demonstrated changes in the electron transport chain induced by sepsis consisting of a reduced respiratory control ratio mainly by a reduced complex I-mediated respiration. Neither an increase in mitochondrial uncoupling nor a reduction in mitochondrial efficiency was demonstrated and cannot explain why oxygen consumption was unaffected despite reduced tubular transport.

Funder

Vetenskapsrådet

Publisher

American Physiological Society

Subject

Physiology

Link

https://journals.physiology.org/doi/pdf/10.1152/ajprenal.00294.2022

Reference37 articles.

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