C1 inhibitor mitigates peritoneal injury in zymosan-induced peritonitis-Reference-Cited by-同舟云学术

C1 inhibitor mitigates peritoneal injury in zymosan-induced peritonitis

Published:2021-06-01 Issue:6 Volume:320 Page:F1123-F1132
ISSN:1931-857X
Container-title:American Journal of Physiology-Renal Physiology
language:en
Short-container-title:American Journal of Physiology-Renal Physiology

Author:

Ozeki Toshikazu¹,Mizuno Masashi¹²,Iguchi Daiki¹,Kojima Hiroshi¹²,Kim Hangsoo¹²,Suzuki Yasuhiro¹²,Kinashi Hiroshi³,Ishimoto Takuji¹^ORCID,Maruyama Shoichi¹,Ito Yasuhiko³

Affiliation:

1. Division of Nephrology, Nagoya University Graduate School of Medicine, Nagoya, Japan

2. Renal Replacement Therapy, Nagoya University Graduate School of Medicine, Nagoya, Japan

3. Department of Nephrology and Rheumatology, Aichi Medical University, Nagakute, Japan

Abstract

Peritoneal injuries associated with peritonitis comprise an important issue to prevent long-term peritoneal dialysis (PD) therapy. Here, we showed that C1 inhibitor (C1-INH), as an anticomplement agent, protected against peritoneal injuries in a peritonitis animal model related to fungal infection. Therefore, C1-INH might be useful to protect against peritoneal injuries after peritonitis due to fungal infection. This clinically available agent may thus help extend the duration of PD.

Funder

the Ministry of Education, Culture, Sports, Science and Technology in Japan Grants-in Aid

the Ministry of Education, Culture, Sports, Science and Technology in Japanese Grants-in Aid

a research grant from the Japanese Association of Dialysis Physicians

Publisher

American Physiological Society

Subject

Physiology

Link

https://journals.physiology.org/doi/pdf/10.1152/ajprenal.00600.2020

Reference47 articles.

1. Selecting Peritoneal Dialysis in the Older Dialysis Population