Role of the renal androgen receptor in sex differences in ammonia metabolism-Reference-Cited by-同舟云学术

Role of the renal androgen receptor in sex differences in ammonia metabolism

Published:2021-11-01 Issue:5 Volume:321 Page:F629-F644
ISSN:1931-857X
Container-title:American Journal of Physiology-Renal Physiology
language:en
Short-container-title:American Journal of Physiology-Renal Physiology

Author:

Harris Autumn N.¹²^ORCID,Castro Rebeca A.¹,Lee Hyun-Wook²,Verlander Jill W.²^ORCID,Weiner I. David²³^ORCID

Affiliation:

1. Department of Small Animal Clinical Science, University of Florida College of Veterinary Medicine, Gainesville, Florida

2. Division of Nephrology, Hypertension and Renal Transplantation, University of Florida College of Medicine, Gainesville, Florida

3. Nephrology and Hypertension Section, Gainesville Veterans Administration Medical Center, Gainesville, Florida

Abstract

Sexual dimorphisms in ammonia metabolism involve androgen receptor (AR)-dependent signaling pathways in male, but not female, kidneys that lead to altered proximal tubule (PT), phosphoenolpyruvate carboxykinase, and thick ascending limb Na+-K+-2Cl− cotransporter expression. Adaptive responses in Na+/H+ exchanger 3 and electrogenic Na+-bicarbonate cotransporter 1-A expression limit the magnitude of the effect on ammonia excretion. Finally, the greater kidney size and PT volume density in male mice is the result of PT androgen signaling through AR.

Funder

HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases

Publisher

American Physiological Society

Subject

Physiology

Link

https://journals.physiology.org/doi/pdf/10.1152/ajprenal.00260.2021

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