The novel STING antagonist H151 ameliorates cisplatin-induced acute kidney injury and mitochondrial dysfunction-Reference-Cited by-同舟云学术

The novel STING antagonist H151 ameliorates cisplatin-induced acute kidney injury and mitochondrial dysfunction

Published:2021-04-01 Issue:4 Volume:320 Page:F608-F616
ISSN:1931-857X
Container-title:American Journal of Physiology-Renal Physiology
language:en
Short-container-title:American Journal of Physiology-Renal Physiology

Author:

Gong Wei¹²³,Lu Lingling¹²³,Zhou Yu¹²³,Liu Jiaye¹²³,Ma Haoyang¹²³,Fu Lvhan¹²³,Huang Songming¹²³,Zhang Yue¹²³,Zhang Aihua¹²³,Jia Zhanjun¹²³^ORCID

Affiliation:

1. Nanjing Key Lab of Pediatrics, Children’s Hospital of Nanjing Medical University, Nanjing, China

2. Jiangsu Key Laboratory of Pediatrics, Nanjing Medical University, Nanjing, China

3. Department of Nephrology, State Key Laboratory of Reproductive Medicine, Children’s Hospital of Nanjing Medical University, Nanjing, China

Abstract

Although various stimulator of interferon genes (STING) inhibitors have been identified, no research was performed to investigate the role of human STING inhibitors in AKI. Here, we evaluated the effect of H151 targeting both human and murine STING on cisplatin-induced AKI and observed a protection against renal injury possibly through ameliorating inflammation and mitochondrial dysfunction.

Funder

National Natural Science Foundation of China

Publisher

American Physiological Society

Subject

Physiology

Link

https://journals.physiology.org/doi/pdf/10.1152/ajprenal.00554.2020

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