Protective effect of <scp>d</scp>-alanine against acute kidney injury-Reference-Cited by-同舟云学术

Protective effect of d-alanine against acute kidney injury

Published:2022-06-01 Issue:6 Volume:322 Page:F667-F679
ISSN:1931-857X
Container-title:American Journal of Physiology-Renal Physiology
language:en
Short-container-title:American Journal of Physiology-Renal Physiology

Author:

Iwata Yasunori¹²^ORCID,Nakade Yusuke²,Kitajima Shinji³²,Yoneda-Nakagawa Shiori²,Oshima Megumi²,Sakai Norihiko³²,Ogura Hisayuki²^ORCID,Sato Koichi²,Toyama Tadashi²,Yamamura Yuta²,Miyagawa Taro²,Yamazaki Hiroka²,Hara Akinori²,Shimizu Miho²,Furuichi Kengo⁴,Mita Masashi⁵,Hamase Kenji⁶,Tanaka Tomohiro⁷,Nishida Motohiro⁶⁷^ORCID,Muramatsu Wataru⁸^ORCID,Yamamoto Hisashi⁸,Shichino Shigeyuki⁹,Ueha Satoshi⁹,Matsushima Kouji⁹,Wada Takashi²

Affiliation:

1. Division of Infection Control, Kanazawa University Hospital, Kanazawa, Japan

2. Department of Nephrology and Laboratory Medicine, Kanazawa University, Kanazawa, Japan

3. Division of Blood Purification, Kanazawa University Hospital, Kanazawa, Japan

4. Division of Nephrology, Kanazawa Medical University School of Medicine, Kanazawa, Japan

5. KAGAMI Incorporated, Osaka, Japan

6. Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka, Japan

7. National Institute for Physiological Sciences and Exploratory Research Center on Life and Living Systems and Center for Novel Science Initiatives, National Institutes of Natural Sciences, Aichi, Japan

8. Molecular Catalyst Research Center, Chubu University, Aichi, Japan

9. Division of Molecular Regulation of Inflammatory and Immune Diseases, Research Institute of Biomedical Sciences, Chiba; Tokyo University of Science, Tokyo, Japan

Abstract

d-Alanine has protective effects on I/R-induced kidney injury. d-Ala inhibits ROS production and improves mitochondrial membrane potential, resulting in reduced TEC necrosis by hypoxic stimulation. The administration of d-Ala protects the tubules from I/R injury in mice. Moreover, the plasma level of d-Ala is conversely associated with eGFR in patients with AKI. Our data suggest that d-Ala is an appealing therapeutic target and a potential biomarker for AKI.

Funder

MEXT | Japan Society for the Promotion of Science

Joint Research of the Exploratory Research Center on Life and Living Systems

Kanazawa University

Publisher

American Physiological Society

Subject

Physiology

Link

https://journals.physiology.org/doi/pdf/10.1152/ajprenal.00198.2021

Reference40 articles.

1. Trends in Hospitalizations for Acute Kidney Injury — United States, 2000–2014