Endothelial cells overexpressing CXCR1/2 are renoprotective in rats with acute kidney injury-Reference-Cited by-同舟云学术

Endothelial cells overexpressing CXCR1/2 are renoprotective in rats with acute kidney injury

Published:2023-04-01 Issue:4 Volume:324 Page:F374-F386
ISSN:1931-857X
Container-title:American Journal of Physiology-Renal Physiology
language:en
Short-container-title:American Journal of Physiology-Renal Physiology

Author:

Xing Dongqi¹^ORCID,Hage Fadi G.²³,Feng Wenguang⁴,Guo Yuanyuan¹,Oparil Suzanne²,Sanders Paul W.⁴⁵³^ORCID

Affiliation:

1. Division of Pulmonary, Allergy and Critical Care Medicine, Lung Health Center, University of Alabama at Birmingham, Birmingham, Alabama, United States

2. Vascular Biology and Hypertension Program, Division of Cardiovascular Disease, University of Alabama at Birmingham, Birmingham, Alabama, United States

3. Birmingham Veterans Affairs Health Care System, Birmingham, Alabama, United States

4. Division of Nephrology, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, United States

5. Department of Cell, Developmental and Integrative Biology, University of Alabama at Birmingham, Birmingham, Alabama, United States

Abstract

Inflammation facilitates kidney ischemia-reperfusion (I/R) injury. Endothelial cells (ECs) that were modified to overexpress (C-X-C motif) chemokine receptor (CXCR)1/2 (CXCR1/2-ECs) were injected immediately following kidney I/R injury. The interaction of CXCR1/2-ECs, but not ECs transduced with an empty adenoviral vector, with injured kidney tissue preserved kidney function and reduced production of inflammatory markers, capillary rarefaction, and interstitial fibrosis. The study highlights a functional role for the C-X-C chemokine pathway in kidney damage following I/R injury.

Funder

HHS | NIH | National Heart, Lung, and Blood Institute

HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases

U.S. Department of Veterans Affairs

Publisher

American Physiological Society

Subject

Physiology

Link

https://journals.physiology.org/doi/pdf/10.1152/ajprenal.00238.2022

Reference49 articles.

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