Commensal microbiota regulate aldosterone

Author:

Moore Brittni N.1ORCID,Medcalf Alexandra D.1,Muir Rachel Q.1,Xu Chudan2ORCID,Marques Francine Z.2ORCID,Pluznick Jennifer L.1ORCID

Affiliation:

1. Department of Physiology, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States

2. School of Biological Sciences, Faculty of Medicine, Monash University, Clayton, Victoria, Australia

Abstract

We explore the role of the gut microbiome in regulating aldosterone, a hormone closely linked to blood pressure and cardiovascular disease. Despite the recognized importance of the gut microbiome in host physiology, the relationship with circulating aldosterone remains largely unexplored. We demonstrate that suppression of gut microbiota leads to increased levels of plasma and urinary aldosterone. These findings underscore the potential of the gut microbiota to influence aldosterone regulation, suggesting new possibilities for treating hypertension.

Funder

American Physiological Society

HHS | National Institutes of Health

Sylvia and Charles Viertel Charitable Foundation

Department of Health, Australian Government | National Health and Medical Research Council

HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases

American Heart Association

DHAC | National Health and Medical Research Council

Publisher

American Physiological Society

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