Affiliation:
1. Department of Physiology, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States
2. School of Biological Sciences, Faculty of Medicine, Monash University, Clayton, Victoria, Australia
Abstract
We explore the role of the gut microbiome in regulating aldosterone, a hormone closely linked to blood pressure and cardiovascular disease. Despite the recognized importance of the gut microbiome in host physiology, the relationship with circulating aldosterone remains largely unexplored. We demonstrate that suppression of gut microbiota leads to increased levels of plasma and urinary aldosterone. These findings underscore the potential of the gut microbiota to influence aldosterone regulation, suggesting new possibilities for treating hypertension.
Funder
American Physiological Society
HHS | National Institutes of Health
Sylvia and Charles Viertel Charitable Foundation
Department of Health, Australian Government | National Health and Medical Research Council
HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases
American Heart Association
DHAC | National Health and Medical Research Council
Publisher
American Physiological Society