Investigating FSGS-like injury in zebrafish larvae by nifurpirinol: efficacy and molecular insight-Reference-Cited by-同舟云学术

Investigating FSGS-like injury in zebrafish larvae by nifurpirinol: efficacy and molecular insight

Published:2024-09-01 Issue:3 Volume:327 Page:F463-F475
ISSN:1931-857X
Container-title:American Journal of Physiology-Renal Physiology
language:en
Short-container-title:American Journal of Physiology-Renal Physiology

Author:

Klawitter Marianne¹^ORCID,Mattias Francescapaola¹,Kliewe Felix¹^ORCID,Hammer Elke²^ORCID,Völker Uwe²^ORCID,Simm Stefan³^ORCID,Siegerist Florian¹^ORCID,Daniel Sophie¹,Schindler Maximilian¹^ORCID,Endlich Nicole¹^ORCID

Affiliation:

1. Department of Anatomy and Cell Biology, University Medicine Greifswald, Greifswald, Germany

2. Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, Greifswald, Germany

3. Institute of Bioinformatics, University Medicine Greifswald, Greifswald, Germany

Abstract

This research investigated the use of nifurpirinol in nanomolar amounts as a prodrug to reliably induce focal segmental glomerulosclerosis (FSGS)-like damage in transgenic zebrafish larvae. Through proteomic analysis of isolated zebrafish glomeruli, we were further able to identify proteins that are significantly regulated after the manifestation of FSGS. These results are expected to expand our knowledge of the pathomechanism of FSGS.

Funder

Bundesministerium für Bildung und Forschung

Bundesministerium für Wirtschaft und Energie

Publisher

American Physiological Society

Link

https://journals.physiology.org/doi/pdf/10.1152/ajprenal.00116.2024

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