A novel functional role for the classic CNS neurotransmitters, GABA, glycine, and glutamate, in the kidney: potent and opposing regulators of the renal vasculature-Reference-Cited by-同舟云学术

A novel functional role for the classic CNS neurotransmitters, GABA, glycine, and glutamate, in the kidney: potent and opposing regulators of the renal vasculature

Published:2023-07-01 Issue:1 Volume:325 Page:F38-F49
ISSN:1931-857X
Container-title:American Journal of Physiology-Renal Physiology
language:en
Short-container-title:American Journal of Physiology-Renal Physiology

Author:

Wildman Scott S.¹,Dunn Kadeshia²,Van Beusecum Justin P.³⁴^ORCID,Inscho Edward W.⁵,Kelley Stephen²,Lilley Rebecca J.²^ORCID,Cook Anthony K.⁵,Taylor Kirsti D.²^ORCID,Peppiatt-Wildman Claire M.²^ORCID

Affiliation:

1. Northeastern University London, London, United Kingdom

2. Division of Natural Sciences, University of Kent, Kent, United Kingdom

3. Ralph H. Johnson Veterans Affairs Medical Center, Charleston, South Carolina, United States

4. Medical University of South Carolina, Charleston, South Carolina, United States

5. Division of Nephrology, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, United States

Abstract

Functional data here offer novel insight into the vasoactive activity of the renal GABA/glutamate system. These data show that activation of endogenous GABA and glutamate receptors in the kidney significantly alters microvessel diameter. Furthermore, the results show that these antiepileptic drugs are as potentially challenging to the kidney as nonsteroidal anti-inflammatory drugs.

Funder

Kidney Research UK

American Heart Association

HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases

HHS | NIH | National Heart, Lung, and Blood Institute

Publisher

American Physiological Society

Subject

Physiology

Link

https://journals.physiology.org/doi/pdf/10.1152/ajprenal.00425.2021

Reference59 articles.