Coupling of renal sodium and calcium transport: a modeling analysis of transporter inhibition and sex differences-Reference-Cited by-同舟云学术

Coupling of renal sodium and calcium transport: a modeling analysis of transporter inhibition and sex differences

Published:2023-11-01 Issue:5 Volume:325 Page:F536-F551
ISSN:1931-857X
Container-title:American Journal of Physiology-Renal Physiology
language:en
Short-container-title:American Journal of Physiology-Renal Physiology

Author:

Hakimi Shervin¹^ORCID,Dutta Pritha¹^ORCID,Layton Anita T.¹²^ORCID

Affiliation:

1. Department of Applied Mathematics, University of Waterloo, Waterloo, Ontario, Canada

2. Department of Biology, Cheriton School of Computer Science, and School of Pharmacology, University of Waterloo, Waterloo, Ontario, Canada

Abstract

The kidney plays an important role in the maintenance of whole body Ca2+ balance by regulating Ca2+ reabsorption and excretion. This computational modeling study provides insights into how Ca2+ transport along the nephron is coupled to Na+. Model results indicated that along the proximal tubule and thick ascending limb, Ca2+ and Na+ transport occur in parallel, but those processes were dissociated in the distal convoluted tubule. Simulations also revealed sex-specific responses to different pharmacological manipulations.

Funder

Canadian Network for Research and Innovation in Machining Technology, Natural Sciences and Engineering Research Council of Canada

Publisher

American Physiological Society

Subject

Physiology

Link

https://journals.physiology.org/doi/pdf/10.1152/ajprenal.00145.2023

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