Deletion of Kir5.1 abolishes the effect of high Na+ intake on Kir4.1 and Na+-Cl− cotransporter-Reference-Cited by-同舟云学术

Deletion of Kir5.1 abolishes the effect of high Na+ intake on Kir4.1 and Na+-Cl− cotransporter

Published:2021-06-01 Issue:6 Volume:320 Page:F1045-F1058
ISSN:1931-857X
Container-title:American Journal of Physiology-Renal Physiology
language:en
Short-container-title:American Journal of Physiology-Renal Physiology

Author:

Duan Xin-Peng¹²,Wu Peng¹³,Zhang Dan-Dan¹⁴,Gao Zhong-Xiuzi¹³,Xiao Yu¹⁵,Ray Evan C.⁶^ORCID,Wang Wen-Hui¹,Lin Dao-Hong¹^ORCID

Affiliation:

1. Department of Pharmacology, New York Medical College, Valhalla, New York

2. Department of Histology and Embryology, Xuzhou Medical University, Xuzhou, People’s Republic of China

3. Institute of Hypertension and Kidney Disease, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, People’s Republic of China

4. Guangdong-Hong Kong Joint Laboratory on Immunological and Genetic Kidney Diseases, Guangdong Academy of Medical Sciences, Guangdong Provincial People’s Hospital, Guangzhou, People’s Republic of China

5. Department of Physiology, Qiqihar Medical University, Qiqihar, People’s Republic of China

6. Renal-Electrolyte Division, University of Pittsburgh, Pittsburgh, Pennsylvania

Abstract

Kir5.1 plays an important role in mediating the effect of high sodium intake on basolateral K+ channels in the distal convoluted tubule and Na+-Cl− cotransporter activity/expression.

Funder

HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases

Publisher

American Physiological Society

Subject

Physiology

Link

https://journals.physiology.org/doi/pdf/10.1152/ajprenal.00004.2021

Reference47 articles.

1. Kir4.1/Kir5.1 Activity Is Essential for Dietary Sodium Intake–Induced Modulation of Na-Cl Cotransporter

2. Kir4.1/Kir5.1 channel forms the major K+channel in the basolateral membrane of mouse renal collecting duct principal cells

3. An inward rectifier K+channel at the basolateral membrane of the mouse distal convoluted tubule: similarities with Kir4‐Kir5.1 heteromeric channels