Blockade of STAT3 signaling alleviates the progression of acute kidney injury to chronic kidney disease through antiapoptosis-Reference-Cited by-同舟云学术

Blockade of STAT3 signaling alleviates the progression of acute kidney injury to chronic kidney disease through antiapoptosis

Published:2022-05-01 Issue:5 Volume:322 Page:F553-F572
ISSN:1931-857X
Container-title:American Journal of Physiology-Renal Physiology
language:en
Short-container-title:American Journal of Physiology-Renal Physiology

Author:

Park Jae Yoon¹,Yoo Kyung Don²^ORCID,Bae Eunjin³,Kim Kyu Hong⁴,Lee Jae Wook⁵,Shin Sung Joon¹,Lee Jong Soo²,Kim Yon Su⁴⁶⁷⁸,Yang Seung Hee⁷⁸^ORCID

Affiliation:

1. Department of Internal Medicine, Dongguk University College of Medicine, Dongguk University Ilsan Hospital, Ilsan, Korea

2. Department of Internal Medicine, Ulsan University Hospital, University of Ulsan College of Medicine, Ulsan, Korea

3. Department of Internal Medicine, Gyeongsang National University College of Medicine, Gyeongsang University Changwon Hospital, Gyeongsang, Korea

4. Department of Biomedical Sciences, College of Medicine, Seoul National University, Seoul, Korea

5. Nephrology Clinic, National Cancer Center of Korea, Seoul, Korea

6. Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea

7. Kidney Research Institute, Seoul National University, Seoul, Korea

8. Biomedical Research Institute, Seoul National University Hospital, Seoul, Korea

Abstract

We found that IRI increased expression of STAT3 in murine kidneys, along with inflammation markers. Through the investigation of the role of STAT3 in the AKI-to-CKD transition mechanism using mouse unilateral IRI and unilateral ureteral obstruction models and 24- or 72-h hypoxic induction of primary cultured human tubular epithelial cells, we found that STAT3 could affect the AKI-to-CKD transition. We also observed different degrees of expression in STAT3 isoforms in these processes.

Funder

National Research Foundation of Korea

Publisher

American Physiological Society

Subject

Physiology

Link

https://journals.physiology.org/doi/pdf/10.1152/ajprenal.00595.2020

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