LAMA improves tissue oxygenation more than LABA in patients with COPD-Reference-Cited by-同舟云学术

LAMA improves tissue oxygenation more than LABA in patients with COPD

Published:2024-07-01 Issue:1 Volume:137 Page:154-165
ISSN:8750-7587
Container-title:Journal of Applied Physiology
language:en
Short-container-title:Journal of Applied Physiology

Author:

Perez-Bogerd Silvia¹^ORCID,Van Muylem Alain¹,Zengin Selim¹,El Khloufi Yasmina¹,Maufroy Emilie²,Faoro Vitalie²,Malinovschi Andrei³^ORCID,Michils Alain¹

Affiliation:

1. Chest Department, Erasme University Hospital, Université Libre de Bruxelles, Brussels, Belgium

2. Cardiopulmonary Exercise Laboratory, Faculty of Motorskill Science, Université Libre de Bruxelles, Brussels, Belgium

3. Department of Medical Sciences: Clinical Physiology, Uppsala University, Uppsala, Sweden

Abstract

Long-acting muscarinic antagonists (LAMAs) significantly improved tissue oxygenation in patients with COPD, while only a trend was observed with β2-agonists (LABAs). The mechanisms involved may differ between drugs: increased peripheral ventilation for LABA and likely lung capillary blood volume for LAMA. This could argue for LAMA as the first therapeutic choice in COPD.

Publisher

American Physiological Society

Link

https://journals.physiology.org/doi/pdf/10.1152/japplphysiol.00467.2023

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