Transient mechanical benefits of a deep inflation in the injured mouse lung-Reference-Cited by-同舟云学术

Transient mechanical benefits of a deep inflation in the injured mouse lung

Published:2002-11-01 Issue:5 Volume:93 Page:1709-1715
ISSN:8750-7587
Container-title:Journal of Applied Physiology
language:en
Short-container-title:Journal of Applied Physiology

Author:

Allen Gilman¹,Lundblad Lennart K. A.¹²,Parsons Polly¹,Bates Jason H. T.¹

Affiliation:

1. Department of Medicine, Vermont Lung Center, University of Vermont, Burlington, Vermont 05405; and

2. Department of Clinical Physiology, MalmöUniversity Hospital, Lund University, 20512 Malmö, Sweden

Abstract

The lasting effects of a recruitment maneuver (RM) in the injured lung are not well characterized. We speculated that the reduction in respiratory elastance ( H) after a deep inflation (DI) is transient in nature and should be sustained longer at higher positive end-expiratory pressure (PEEP). Thirteen ventilated mice were given 2 DIs at various levels of PEEP before and after saline lavage. Forced oscillations were used to measure H periodically over 7 min after the DIs. Time constants (τ) were estimated for the post-DI recovery in H. Values for τ before lavage (80–115 s) were reduced after lavage (13–30 s) at all levels of PEEP ( P = 0.0001). PEEP did not significantly influence τ before or after lavage. The plateau level and total recovery in H after a DI were significantly influenced by PEEP and lavage ( P < 0.0001). Our results suggest that for a DI to be beneficial in the injured mouse lung, it may have to be applied several times a minute.

Publisher

American Physiological Society

Subject

Physiology (medical),Physiology

Link

https://www.physiology.org/doi/pdf/10.1152/japplphysiol.00473.2002

Reference38 articles.

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2. Effect of a Protective-Ventilation Strategy on Mortality in the Acute Respiratory Distress Syndrome

3. Impaired Oxygenation in Surgical Patients during General Anesthesia with Controlled Ventilation

4. Volume recruitment maneuvers are less deleterious than persistent low lung volumes in the atelectasisprone rabbit lung during high-frequency oscillation

5. Sustained inflations improve respiratory compliance during high-frequency oscillatory ventilation but not during large tidal volume positive-pressure ventilation in rabbits

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