Sacubitril-valsartan improves conduit vessel function and functional capacity and reduces inflammation in heart failure with reduced ejection fraction-Reference-Cited by-同舟云学术

Sacubitril-valsartan improves conduit vessel function and functional capacity and reduces inflammation in heart failure with reduced ejection fraction

Published:2021-01-01 Issue:1 Volume:130 Page:256-268
ISSN:8750-7587
Container-title:Journal of Applied Physiology
language:en
Short-container-title:Journal of Applied Physiology

Author:

Bunsawat Kanokwan¹^ORCID,Ratchford Stephen M.¹²³^ORCID,Alpenglow Jeremy K.⁴,Park Soung Hun⁴,Jarrett Catherine L.¹²^ORCID,Stehlik Josef⁵,Smith Adam S.⁶,Richardson Russell S.¹²⁴,Wray D. Walter¹²⁴

Affiliation:

1. Division of Geriatrics, Department of Internal Medicine, University of Utah, Salt Lake City, Utah

2. Geriatric Research, Education, and Clinical Center, George E. Wahlen Department of Veterans Affairs Medical Center, Salt Lake City, Utah

3. Department of Health & Exercise Science, Appalachian State University, Boone, North Carolina

4. Department of Nutrition and Integrative Physiology, University of Utah, Salt Lake City, Utah

5. Division of Cardiovascular Medicine, Department of Internal Medicine, University of Utah, Salt Lake City, Utah

6. Department of Pharmacy Services, University of Utah, Salt Lake City, Utah

Abstract

We observed an approximately twofold improvement in conduit vessel function (brachial artery FMD), increased functional capacity (6MWT distance), and a reduction in inflammation (TNF-α and IL-18) following 3 mo of sacubitril-valsartan therapy. These findings provide important new information concerning the physiological mechanisms by which this new drug class provokes favorable changes in HFrEF pathophysiology.

Funder

American Heart Association

HHS | National Institutes of Health

U.S. Department of Veterans Affairs

Publisher

American Physiological Society

Subject

Physiology (medical),Physiology

Link

https://journals.physiology.org/doi/pdf/10.1152/japplphysiol.00454.2020

Reference87 articles.

1. The Mechanism of Action of LCZ696