Sex- and age-based differences in the effect of central serotonin on arterial blood pressure regulation-Reference-Cited by-同舟云学术

Sex- and age-based differences in the effect of central serotonin on arterial blood pressure regulation

Published:2020-12-01 Issue:6 Volume:129 Page:1310-1323
ISSN:8750-7587
Container-title:Journal of Applied Physiology
language:en
Short-container-title:Journal of Applied Physiology

Author:

Magnusson Jennifer L.¹,Emter Craig A.¹^ORCID,Cummings Kevin J.¹²^ORCID

Affiliation:

1. Department of Biomedical Sciences, College of Veterinary Medicine, University of Missouri, Columbia, Missouri

2. Dalton Cardiovascular Research Center, University of Missouri, Columbia, Missouri

Abstract

The role of serotonin in arterial blood pressure (ABP) regulation across states of vigilance is unknown. We hypothesized that adult rats devoid of CNS serotonin (TPH2−/−) have low ABP in wakefulness and NREM sleep, when serotonin neurons are active. However, TPH2−/− rats experience higher ABP than TPH2+/+ rats in wakefulness and REM only, a phenotype present only in older males and not females. CNS serotonin may be critical for preventing high ABP in males with aging.

Funder

HHS | National Institutes of Health

Publisher

American Physiological Society

Subject

Physiology (medical),Physiology

Link

https://journals.physiology.org/doi/pdf/10.1152/japplphysiol.00414.2020

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