Long-term physical inactivity exacerbates hindlimb unloading-induced muscle atrophy in young rat soleus muscle-Reference-Cited by-同舟云学术

Long-term physical inactivity exacerbates hindlimb unloading-induced muscle atrophy in young rat soleus muscle

Published:2021-04-01 Issue:4 Volume:130 Page:1214-1225
ISSN:8750-7587
Container-title:Journal of Applied Physiology
language:en
Short-container-title:Journal of Applied Physiology

Author:

Yoshihara Toshinori¹²^ORCID,Natsume Toshiharu¹,Tsuzuki Takamasa³,Chang Shuo-Wen²,Kakigi Ryo²⁴,Machida Shuichi¹²,Sugiura Takao⁵,Naito Hisashi¹²^ORCID

Affiliation:

1. Graduate School of Health and Sports Science, Juntendo University, Inzai, Chiba, Japan

2. Faculty of Health and Sports Science, Juntendo University, Inzai, Chiba, Japan

3. Faculty of Pharmacy, Meijo University, Nagoya, Aichi, Japan

4. Faculty of Management & Information Sciences, Josai International University, Togane, Chiba, Japan

5. Faculty of Education, Yamaguchi University, Yoshida, Yamaguchi, Japan

Abstract

NEW & NOTEWORTHY: Long-term physical inactivity exacerbates hindlimb unloading-induced disuse muscle atrophy in young rat soleus muscles, possibly mediated by oxidative stress-induced protein ubiquitination via HDAC4- and NF-κB p65-induced MuRF1 mRNA upregulation.

Funder

MEXT | Japan Society for the Promotion of Science

Joint Research Program of Juntendo 489 University, Faculty of Health and Sports Science

Publisher

American Physiological Society

Subject

Physiology (medical),Physiology

Link

https://journals.physiology.org/doi/pdf/10.1152/japplphysiol.00494.2020

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1. All-Cause Mortality Attributable to Sitting Time

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