Author:
Kovar Jana,Willet Karen E.,Hislop Alison,Sly Peter D.
Abstract
Inhaled glucocorticoid treatment during the first 2 yr of life is controversial because this is a period of major structural remodeling of the lung. Rabbits received aerosolized budesonide (Bud; 250 μg/ml) or injected dexamethasone (Dex; 0.05 mg·ml−1·kg−1) between 1 and 5 wk of age. Treatment with Bud caused specific growth retardation of the lung. Dex but not Bud affected the mechanical properties of the lung parenchyma, when corrected for lung volume. Small peripheral airway walls in both glucocorticoid groups were thinner and had fewer alveolar attachment points with greater distance between attachments than controls, but collagen content was not affected by glucocorticoids. Dex led to reduced body weight, lung volume, alveolar number, and surface area. The alveolar size and number and elastin content, when related to lung volume, was not affected by Bud, suggesting normal structural development but inhibition of total growth. Arterial wall thickness and diameter were affected by Bud. This study demonstrates that developing lungs are sensitive to inhaled glucocorticoids. As such, the use of glucocorticoids in young infants and children should be monitored with caution and only the lowest doses that yield significant clinical improvement should be used.
Publisher
American Physiological Society
Subject
Physiology (medical),Physiology
Reference30 articles.
1. Inhibition of lysyl oxidase and prolyl hydroxylase activity in glucorcorticoid treated rats
2. Blanco LN, Massaro GD, and Massaro D. Alveolar dimensions and number: developmental and hormonal regulation. Am J Physiol Lung Cell Mol Physiol 257: L240–L247, 1989.
3. Brody JS, Kagan H, and Manalo A. Lung lysyl oxidase activity: relation to lung growth. Am Rev Respir Dis 120: 1289–1295, 1979.
4. Growth of the alveoli and pulmonary arteries in childhood
5. Apoptosis of Airway Epithelial Cells Induced by Corticosteroids
Cited by
32 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献