Fast and slow muscle fiber transcriptome dynamics with lifelong endurance exercise-Reference-Cited by-同舟云学术

Fast and slow muscle fiber transcriptome dynamics with lifelong endurance exercise

Published:2024-02-01 Issue:2 Volume:136 Page:244-261
ISSN:8750-7587
Container-title:Journal of Applied Physiology
language:en
Short-container-title:Journal of Applied Physiology

Author:

Raue Ulrika¹,Begue Gwenaelle¹^ORCID,Minchev Kiril¹,Jemiolo Bozena¹,Gries Kevin J.¹^ORCID,Chambers Toby¹,Rubenstein Aliza²,Zaslavsky Elena²,Sealfon Stuart C.²,Trappe Todd¹^ORCID,Trappe Scott¹^ORCID

Affiliation:

1. Human Performance Laboratory, Ball State University, Muncie, Indiana, United States

2. Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, New York, United States

Abstract

This study provides the first insights into fast and slow muscle fiber transcriptome dynamics with lifelong endurance exercise. The fast fibers were more responsive to exercise with divergent transcriptome signatures among young exercisers (growth and metabolic), lifelong exercisers (metabolic), and old healthy nonexercisers (stress). Only lifelong exercisers had a biological response in slow fibers (metabolic). These data provide novel insights into fast and slow muscle fiber health at the molecular level with age and exercise.

Funder

HHS | National Institutes of Health

Ball State University Human Bioenergetics Program

Publisher

American Physiological Society

Subject

Physiology (medical),Physiology

Link

https://journals.physiology.org/doi/pdf/10.1152/japplphysiol.00442.2023

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