Protective ventilation in a pig model of acute lung injury: timing is as important as pressure-Reference-Cited by-同舟云学术

Protective ventilation in a pig model of acute lung injury: timing is as important as pressure

Published:2022-11-01 Issue:5 Volume:133 Page:1093-1105
ISSN:8750-7587
Container-title:Journal of Applied Physiology
language:en
Short-container-title:Journal of Applied Physiology

Author:

Ramcharran Harry¹,Bates Jason H. T.²^ORCID,Satalin Joshua¹^ORCID,Blair Sarah¹,Andrews Penny L.³,Gaver Donald P.⁴,Gatto Louis A.¹,Wang Guirong¹,Ghosh Auyon J.¹,Robedee Benjamin¹,Vossler James¹,Habashi Nader M.³,Daphtary Nirav²,Kollisch-Singule Michaela¹,Nieman Gary F.¹^ORCID

Affiliation:

1. SUNY Upstate Medical University, Syracuse, New York

2. University of Vermont, Burlington, Vermont

3. R Adams Cowley Shock Trauma Center, Baltimore, Maryland

4. Tulane University, New Orleans, Louisiana

Abstract

In a large animal model of ARDS, recruitment/derecruitment caused greater VILI than overdistension, whereas both mechanisms together caused severe lung damage. These findings suggest that eliminating cyclic recruitment and derecruitment during mechanical ventilation should be a preeminent management goal for the patient with ARDS. The airway pressure release ventilation (APRV) mode of mechanical ventilation can achieve this if delivered with an expiratory duration (TLow) that is brief enough to prevent derecruitment at end expiration.

Funder

DOD | US Army | MEDCOM | Congressionally Directed Medical Research Programs

HHS | NIH | National Heart, Lung, and Blood Institute

Publisher

American Physiological Society

Subject

Physiology (medical),Physiology

Link

https://journals.physiology.org/doi/pdf/10.1152/japplphysiol.00312.2022

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