Effects of hydroxyurea on skeletal muscle energetics and force production in a sickle cell disease murine model

Abstract

Our results highlighted that force production decreases between 2 and 4 mo of age in SCD mice thereby indicating a decrease of muscle function during this period. Of interest, HU treatment seemed to blunt the observed age effect given that SCD4 m-HU mice displayed a higher specific force production as compared with SCD4 m mice. In that respect, HU treatment would help to maintain a higher capacity of force production during aging in SCD.