Effects of combined treatment with blood flow restriction and low-current electrical stimulation on capillary regression in the soleus muscle of diabetic rats-Reference-Cited by-同舟云学术

Effects of combined treatment with blood flow restriction and low-current electrical stimulation on capillary regression in the soleus muscle of diabetic rats

Published:2021-10-01 Issue:4 Volume:131 Page:1219-1229
ISSN:8750-7587
Container-title:Journal of Applied Physiology
language:en
Short-container-title:Journal of Applied Physiology

Author:

Tanaka Minoru¹²³^ORCID,Morifuji Takeshi¹⁴,Sugimoto Ken⁵,Akasaka Hiroshi²,Fujimoto Taku²,Yoshikawa Madoka¹,Nakanishi Ryosuke¹⁶,Kondo Hiroyo¹,Fujino Hidemi¹^ORCID

Affiliation:

1. Department of Rehabilitation Science, Kobe University Graduate School of Health Science, Kobe, Japan

2. Department of Geriatric and General Medicine, Osaka University Graduate School of Medicine, Suita, Japan

3. Department of Rehabilitation Science, Osaka Health Science University, Osaka, Japan

4. Department of Physical Therapy, Josai International University, Togane, Japan

5. General and Geriatric Medicine, Kawasaki Medical School General Medical Center, Okayama, Japan

6. Faculty of Rehabilitation, Department of Physical Therapy, Kobe International University, Kobe, Japan

Abstract

The combined treatment of blood flow restriction and low intensity electrical stimulation attenuated type 2 diabetes (T2D)-associated capillary regression in the skeletal muscles. The treatment inhibits the T2D-associated increase in antiangiogenic factors via inhibition of intramuscular chronic hypoxia; it can inhibit intramuscular chronic hypoxia by enhancing proangiogenic factors. These results suggest that the combined treatment may be an effective therapeutic intervention for the prevention of T2D-associated capillary regression in the skeletal muscles.

Funder

MEXT | Japan Society for the Promotion of Science

Publisher

American Physiological Society

Subject

Physiology (medical),Physiology

Link

https://journals.physiology.org/doi/pdf/10.1152/japplphysiol.00366.2021

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1. Diabetic kidney disease: act now or pay later

2. Low-intensity running exercise enhances the capillary volume and pro-angiogenic factors in the soleus muscle of type 2 diabetic rats

3. Regulation of skeletal muscle morphology in type 2 diabetic subjects by troglitazone and metformin: Relationship to glucose disposal