Genetic polymorphisms in <i>CYP19A1</i> and <i>ESR1</i> are associated with serum CK activity after prolonged running in men-Reference-Cited by-同舟云学术

Genetic polymorphisms in CYP19A1 and ESR1 are associated with serum CK activity after prolonged running in men

Published:2022-04-01 Issue:4 Volume:132 Page:966-973
ISSN:8750-7587
Container-title:Journal of Applied Physiology
language:en
Short-container-title:Journal of Applied Physiology

Author:

Kumagai Hiroshi¹^ORCID,Miyamoto-Mikami Eri¹,Takaragawa Mizuki¹,Kuriki Kiyonori²,Goto Chiho³,Shibata Kiyoshi⁴,Yamada Norihiro⁵,Hosono Akihiro⁶⁷,Fuku Mizuho¹⁸,Suzuki Sadao⁷,Fuku Noriyuki¹

Affiliation:

1. Graduate School of Health and Sports Science, Juntendo University, Chiba, Japan

2. School of Food and Nutritional Sciences, University of Shizuoka, Shizuoka, Japan

3. Faculty of Health and Human Life, Nagoya Bunri University, Inazawa, Japan

4. Department of Human Life and Sciences, Nagoya University of Economics, Inuyama, Japan

5. Faculty of Agriculture, Setsunan University, Hirakata, Japan

6. Meito Health Center, Nagoya, Japan

7. Department of Public Health, Nagoya City University, Nagoya, Japan.

8. Department of Rehabilitation Medicine, Tsudanuma Central General Hospital, Chiba, Japan

Abstract

Men with the TT genotype of the CYP19A1 polymorphism exhibited higher circulating estradiol levels than the TC + CC genotype. The TT genotype in the CYP19A1 polymorphism and the C allele of the ESR1 polymorphism, an allele increasing ESR1 expression, were associated with low serum CK activity after the ultramarathon. A combination of these polymorphisms was correlated with changes in the serum CK activity. Therefore, estrogen-related genetic polymorphisms partially predict exercise-induced muscle damage, that is, skeletal muscle membrane disruption.

Funder

MEXT | Japan Society for the Promotion of Science

Institute of Health and Sports Science and Medicine, Juntendo University

Publisher

American Physiological Society

Subject

Physiology (medical),Physiology

Link

https://journals.physiology.org/doi/pdf/10.1152/japplphysiol.00374.2021

Reference38 articles.

1. Genetic variation and exercise-induced muscle damage: implications for athletic performance, injury and ageing

2. Exercise-Induced Muscle Damage in Humans

3. Running Pace Decrease during a Marathon Is Positively Related to Blood Markers of Muscle Damage

4. Effect of Slow-Velocity Lengthening Contractions on Muscle Damage Induced by Fast-Velocity Lengthening Contractions

5. Contralateral Repeated Bout Effect of Eccentric Exercise of the Elbow Flexors

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