Impact of glutamine supplementation on glucose homeostasis during and after exercise

Author:

Iwashita Soh,Williams Phillip,Jabbour Kareem,Ueda Takeo,Kobayashi Hisamine,Baier Shawn,Flakoll Paul J.

Abstract

The interaction of glutamine availability and glucose homeostasis during and after exercise was investigated, measuring whole body glucose kinetics with [3-3H]glucose and net organ balances of glucose and amino acids (AA) during basal, exercise, and postexercise hyperinsulinemic-euglycemic clamp periods in six multicatheterized dogs. Dogs were studied twice in random treatment order: once with glutamine (12 μmol·kg−1·min−1; Gln) and once with saline (Con) infused intravenously during and after exercise. Plasma glucose fell by 7 mg/dl with exercise in Con ( P < 0.05), but it did not fall with Gln. Gln further stimulated whole body glucose production and utilization an additional 24% above a normal exercise response ( P < 0.05). Net hepatic uptake of glutamine and alanine was greater with Gln than Con during exercise ( P < 0.05). Net hepatic glucose output was increased sevenfold during exercise with Gln ( P < 0.05) but not with Con. Net hindlimb glucose uptake was increased similarly during exercise in both groups ( P < 0.05). During the postexercise hyperinsulinemic-euglycemic period, glucose production decreased to near zero with Con, but it did not decrease below basal levels with Gln. Gln increased glucose utilization by 16% compared with Con after exercise ( P < 0.05). Furthermore, net hindlimb glucose uptake in the postexercise period was increased approximately twofold vs. basal with Gln ( P < 0.05) but not with Con. Net hepatic uptake of glutamine during the postexercise period was threefold greater for Gln than Con ( P < 0.05). In conclusion, glutamine availability modulates glucose homeostasis during and after exercise, which may have implications for postexercise recovery.

Publisher

American Physiological Society

Subject

Physiology (medical),Physiology

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